TASKS
PUBLIC INTERVENTIONS AND INFORMATIONS
RESEARCH
Tasks:
Work group at Université Paris Dauphine – PSL: follow this link.
Old position: chair of the RDA-COVID19-Epidemiology group.
Scientific committee:…
Public interventions:
- summary of a interview at the OPECST (Assemblée Nationale et Sénat); PDF here and Youtube
video here - an interview for the Dauphine alumni newsletter (October 2020 Issue)
– GdT Covid intervention: vidéo here
– Some information on the French Mathematical Society site / CNRS version
Research
COVID-19 adaptive humoral immunity models
The individual immunity plays an important role for the patients’ COVID-19 outcome. We propose in this work a numerical model that describes the interaction between the immune system of the host (patient) and the invading SARS-CoC-2 virus. We discuss two important topics (non-neutralizing antibodies and antibody-depencent enhancement phynomena (ADE) and its consequences for vaccination and secondary infection(s).
Immunity after COVID-19: protection or sensitization ?
This work with Antoine Danchin asks the question of the consequences of a first infection with SARS-CoV-2: does a first infection builds immunity or on the contrary will a second infection be more severe due to ADE mechanisms, what are the likely impact of such a phenomenon.
2020: Lockdown : the forecasts that do not take into account different transmission rates within different types of individuals (general population, medical doctors, etc.) will likely be pessimistic. Mathematical proof here.
2020: Will individuals respect the lockdown ?
The inviduals will likely lockdown early but will not follow the societal lockup prescriptions when the epidemic delines (published in Mathematical Modelling of Natural Phenomena, open access)
Simultaneous experimental validations:
– individuals will lockdown by themselves early (https://arxiv.org/abs/2004.14748)
– individuals will end lockdown early than advised: https://www.huffingtonpost.fr/entry/le-maintien-du-confinement-soutenu-par-moins-dun-francais-sur-deux-sondage-exclusif_fr_5ea3080bc5b6f96398140f82
Présentation at Health Data Hub France 13/5/2020: SLIDES HERE
2020: SARS-CoV-2 / COVID-19 propagation: the role of asymptomatics and transmission routes.
A short Youtube video (in French) presenting this work: https://www.youtube.com/watch?v=EeZn5LqGTE0
2003 propagation paper: A double epidemic model for the SARS propagation, published in BMC Infect. Diseases.
2006/07 paper: with arguments that SARS will return (!!) published in Encyclopaedia of Infectious Diseases, 2007, free version here